Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase.

Abstract

The F-box proteins are the substrate recognition subunits of the SCF (Skp1-Cul1-Rbx1-F- box protein) ubiquitin ligase complexes that control the stability of numerous regulators in eukaryotic cells. Here we show that dimerization of the F-box protein Fbx4 is essential for SCF(Fbx4) (the superscript denotes the F-box protein) ubiquitination activity toward… (More)
DOI: 10.1074/jbc.M110.111518

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