Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues

@inproceedings{Coey2016StructuralBO,
  title={Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues},
  author={Christopher Coey and Shuja S. Malik and Lakshmi Swarna Mukhi Pidugu and Kristen M. Varney and Edwin V Pozharski and Alexander C. Drohat},
  booktitle={Nucleic acids research},
  year={2016}
}
Thymine DNA Glycosylase (TDG) is a base excision repair enzyme functioning in DNA repair and epigenetic regulation. TDG removes thymine from mutagenic G·T mispairs arising from deamination of 5-methylcytosine (mC), and it processes other deamination-derived lesions including uracil (U). Essential for DNA demethylation, TDG excises 5-formylcytosine and 5-carboxylcytosine, derivatives of mC generated by Tet (ten-eleven translocation) enzymes. Here, we report structural and functional studies of… CONTINUE READING
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