Structural basis of collagen fiber degradation by cathepsin K.

@article{Aguda2014StructuralBO,
  title={Structural basis of collagen fiber degradation by cathepsin K.},
  author={Adeleke Halilu Aguda and Preety Panwar and Xin Du and Nham T. Nguyen and Gary D. Brayer and Dieter Br{\"o}mme},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 49},
  pages={
          17474-9
        }
}
Cathepsin K is the major collagenolytic protease in bone that facilitates physiological as well as pathological bone degradation. Despite its key role in bone remodeling and for being a highly sought-after drug target for the treatment of osteoporosis, the mechanism of collagen fiber degradation by cathepsin K remained elusive. Here, we report the structure of a collagenolytically active cathepsin K protein dimer. Cathepsin K is organized into elongated C-shaped protease dimers that reveal a… CONTINUE READING
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Structural basis for matrix metalloproteinase 1-catalyzed collagenolysis

  • I Bertini
  • J Am Chem Soc 134(4):–2110
  • 2012
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