Structural basis of cell–cell adhesion by NCAM

  title={Structural basis of cell–cell adhesion by NCAM},
  author={Christina Kasper and Hanne Marie Skyggedal Rasmussen and Jette Sandholm Kastrup and Shinji Ikemizu and E Yvonne Jones and Vladimir Berezin and Elisabeth Bock and Ingrid Kj\oller Larsen},
  journal={Nature Structural Biology},
The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell–cell recognition and adhesion via a homophilic interaction. NCAM plays a key role during development and regeneration of the nervous system and is involved in synaptic plasticity associated with memory and learning. The 1.85 Å crystal structure of the two N-terminal extracellular domains of NCAM reported here provides a structural basis for the homophilic interaction. The molecular packing of the… CONTINUE READING

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