Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling.

@article{Podgornaia2013StructuralBO,
  title={Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling.},
  author={Anna Igorevna Podgornaia and Patricia Casino and Alberto Marina and Michael T Laub},
  journal={Structure},
  year={2013},
  volume={21 9},
  pages={1636-47}
}
Two-component signal transduction systems typically involve a sensor histidine kinase that specifically phosphorylates a single, cognate response regulator. This protein-protein interaction relies on molecular recognition via a small set of residues in each protein. To better understand how these residues determine the specificity of kinase-substrate interactions, we rationally rewired the interaction interface of a Thermotoga maritima two-component system, HK853-RR468, to match that found in a… CONTINUE READING
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