Structural basis of a phototropin light switch.

@article{Harper2003StructuralBO,
  title={Structural basis of a phototropin light switch.},
  author={Shannon M Harper and Lori C Neil and Kevin H Gardner},
  journal={Science},
  year={2003},
  volume={301 5639},
  pages={1541-4}
}
Phototropins are light-activated kinases important for plant responses to blue light. Light initiates signaling in these proteins by generating a covalent protein-flavin mononucleotide (FMN) adduct within sensory Per-ARNT-Sim (PAS) domains. We characterized the light-dependent changes of a phototropin PAS domain by solution nuclear magnetic resonance spectroscopy and found that an alpha helix located outside the canonical domain plays a key role in this activation process. Although this helix… CONTINUE READING
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