Structural basis of Zika virus helicase in recognizing its substrates

@inproceedings{Tian2016StructuralBO,
  title={Structural basis of Zika virus helicase in recognizing its substrates},
  author={Hongliang Tian and Xiaoyun Ji and Xiaoyun Shawn Yang and Zhongxin Zhang and Zuokun Lu and Kailin Yang and Cheng Chen and Qi Zhao and Heng Chi and Zhongyu Mu and Wei Xie and Zefang Wang and Huiqiang Lou and Haitao Yang and Zihe Rao},
  booktitle={Protein & Cell},
  year={2016}
}
The recent explosive outbreak of Zika virus (ZIKV) infection has been reported in South and Central America and the Caribbean. Neonatal microcephaly associated with ZIKV infection has already caused a public health emergency of international concern. No specific vaccines or drugs are currently available to treat ZIKV infection. The ZIKV helicase, which plays a pivotal role in viral RNA replication, is an attractive target for therapy. We determined the crystal structures of ZIKV helicase-ATP… CONTINUE READING
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Discovery and Computational Analyses of Novel Small Molecule Zika Virus Inhibitors

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