• DOI:10.1101/gad.1865310
Corpus ID: 12437787

Structural basis of YAP recognition by TEAD4 in the hippo pathway.

@article{Chen2010StructuralBO,
  title={Structural basis of YAP recognition by TEAD4 in the hippo pathway.},
  author={L. Chen and S. W. Chan and Xiaoqian Zhang and M. Walsh and C. J. Lim and W. Hong and H. Song},
  journal={Genes & development},
  year={2010},
  volume={24 3},
  pages={
          290-300
        }
}

L. Chen, S. W. Chan, +4 authors H. Song

Published 2010

Biology, Medicine

Genes & development

The Hippo signaling pathway controls cell growth, proliferation, and apoptosis by regulating the expression of target genes that execute these processes. Acting downstream from this pathway is the YAP transcriptional coactivator, whose biological function is mediated by the conserved TEAD family transcription factors. The interaction of YAP with TEADs is critical to regulate Hippo pathway-responsive genes. Here, we describe the crystal structure of the YAP-interacting C-terminal domain of TEAD4… CONTINUE READING

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