Structural basis of Streptococcus pyogenes immunity to its NAD+ glycohydrolase toxin.

@article{Smith2011StructuralBO,
  title={Structural basis of Streptococcus pyogenes immunity to its NAD+ glycohydrolase toxin.},
  author={Craig L Smith and Joydeep Ghosh and Jennifer Stine Elam and Jerome S Pinkner and Scott J Hultgren and Michael G Caparon and Tom E. Ellenberger},
  journal={Structure},
  year={2011},
  volume={19 2},
  pages={192-202}
}
The virulence of Gram-positive bacteria is enhanced by toxins like the Streptococcus pyogenes β-NAD(+) glycohydrolase known as SPN. SPN-producing strains of S. pyogenes additionally express the protein immunity factor for SPN (IFS), which forms an inhibitory complex with SPN. We have determined crystal structures of the SPN-IFS complex and IFS alone, revealing that SPN is structurally related to ADP-ribosyl transferases but lacks the canonical binding site for protein substrates. SPN is instead… CONTINUE READING