Structural basis of SH2 domain mutations in X-linked agammaglobulinemia.

  title={Structural basis of SH2 domain mutations in X-linked agammaglobulinemia.},
  author={Mauno Vihinen and Lennart Nilsson and C I Edvard Smith},
  journal={Biochemical and biophysical research communications},
  volume={205 2},
The three-dimensional structure of Bruton's agammaglobulinemia tyrosine kinase (Btk) SH2 domain was modeled based on v-Src. Btk SH2 is presumably very related to the other SH2 structures consisting of two beta-sheets surrounded by two alpha-helices, with a well conserved hydrophobic core and phoshotyrosyl peptide binding site. The model was used to predict the recognition sequence of the target protein, which probably is YEXI/L. Mutations in the Btk sequence can cause the human disease X-linked… CONTINUE READING

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