Structural basis of Ets1 cooperative binding to palindromic sequences on stromelysin-1 promoter DNA.

@article{Babayeva2010StructuralBO,
  title={Structural basis of Ets1 cooperative binding to palindromic sequences on stromelysin-1 promoter DNA.},
  author={Nigar D. Babayeva and P. J. Wilder and Masaaki Shiina and Koshiki Mino and Michelle Desler and Kazuhiro Ogata and Angie Rizzino and Tahir H. Tahirov},
  journal={Cell cycle},
  year={2010},
  volume={9 15},
  pages={3054-62}
}
Ets1 is a member of the Ets family of transcription factors. Ets1 is autoinhibited and its activation requires heterodimerization with a partner protein or DNA-mediated homodimerization for cooperative DNA binding. In the latter case, Ets1 molecules bind to palindromic sequences in which two Ets-binding sites (EBS) are separated by four base pairs, for example in the promoters of stromelysin-1 and p53. Interestingly, counteraction of autoinhibition requires the autoinhibitory region encoded by… CONTINUE READING

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