Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme

  title={Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme},
  author={Geoffrey Masuyer and Ross G. Douglas and Edward D. Sturrock and Keshab R. Acharya},
  booktitle={Scientific reports},
Angiotensin-I converting enzyme (ACE) is a zinc dipeptidylcarboxypeptidase with two active domains and plays a key role in the regulation of blood pressure and electrolyte homeostasis, making it the principal target in the treatment of cardiovascular disease. More recently, the tetrapetide N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) has emerged as a potent antifibrotic agent and negative regulator of haematopoietic stem cell differentiation which is processed exclusively by ACE. Here we provide a… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS