Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme

@inproceedings{Masuyer2015StructuralBO,
  title={Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme},
  author={Geoffrey Masuyer and Ross G. Douglas and Edward D. Sturrock and Keshab R. Acharya},
  booktitle={Scientific reports},
  year={2015}
}
Angiotensin-I converting enzyme (ACE) is a zinc dipeptidylcarboxypeptidase with two active domains and plays a key role in the regulation of blood pressure and electrolyte homeostasis, making it the principal target in the treatment of cardiovascular disease. More recently, the tetrapetide N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) has emerged as a potent antifibrotic agent and negative regulator of haematopoietic stem cell differentiation which is processed exclusively by ACE. Here we provide a… CONTINUE READING
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