Structural basis of ARNT PAS-B dimerization: use of a common beta-sheet interface for hetero- and homodimerization.

@article{Card2005StructuralBO,
  title={Structural basis of ARNT PAS-B dimerization: use of a common beta-sheet interface for hetero- and homodimerization.},
  author={Paul B. Card and Paul J A Erbel and Kevin H Gardner},
  journal={Journal of molecular biology},
  year={2005},
  volume={353 3},
  pages={664-77}
}
The aryl hydrocarbon receptor nuclear translocator (ARNT) is a promiscuous bHLH-PAS (Per-ARNT-Sim) protein that forms heterodimeric transcriptional regulator complexes with several other bHLH-PAS subunits to control a variety of biological pathways, some of which are centrally involved in disease initiation and/or progression. One of these is the hypoxia response pathway, which allows eukaryotic cells to respond to low oxygen tension via the formation of a heterodimeric complex between ARNT and… CONTINUE READING