Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1.

@article{Egloff1997StructuralBF,
  title={Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1.},
  author={Marie Pierre Egloff and Dale F. Johnson and GBG. Moorhead and Philip Cohen and David Barford},
  journal={The EMBO journal},
  year={1997},
  volume={16 8},
  pages={1876-87}
}
The diverse forms of protein phosphatase 1 in vivo result from the association of its catalytic subunit (PP1c) with different regulatory subunits, one of which is the G-subunit (G(M)) that targets PP1c to glycogen particles in muscle. Here we report the structure, at 3.0 A resolution, of PP1c in complex with a 13 residue peptide (G(M[63-75])) of G(M). The residues in G(M[63-75]) that interact with PP1c are those in the Arg/Lys-Val/Ile-Xaa-Phe motif that is present in almost every other… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
154 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 154 extracted citations

Similar Papers

Loading similar papers…