Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein

  title={Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein},
  author={Jovan Nikolic and Laura Belot and H{\'e}l{\`e}ne Raux and Pierre Legrand and Yves Gaudin and Aur{\'e}lie A Albertini},
  booktitle={Nature Communications},
Vesicular stomatitis virus (VSV) is an oncolytic rhabdovirus and its glycoprotein G is widely used to pseudotype other viruses for gene therapy. Low-density lipoprotein receptor (LDL-R) serves as a major entry receptor for VSV. Here we report two crystal structures of VSV G in complex with two distinct cysteine-rich domains (CR2 and CR3) of LDL-R, showing that their binding sites on G are identical. We identify two basic residues on G, which are essential for its interaction with CR2 and CR3… CONTINUE READING
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