Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy

@article{Kuang2016StructuralBF,
  title={Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy},
  author={Yao Kuang and K. Ma and Changqian Zhou and P. Ding and Yushan Zhu and Quan Chen and B. Xia},
  journal={Autophagy},
  year={2016},
  volume={12},
  pages={2363 - 2373}
}
ABSTRACT Mitophagy is a fundamental process that determines mitochondrial quality and homeostasis. Several mitophagy receptors, including the newly identified FUNDC1, mediate selective removal of damaged or superfluous mitochondria through their specific interaction with LC3. However, the precise mechanism by which this interaction is regulated to initiate mitophagy is not understood. Here, we report the solution structure of LC3 in complex with a peptide containing the FUNDC1 LC3-interacting… Expand
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