Structural basis for the lack of opposite base specificity of Clostridium acetobutylicum 8-oxoguanine DNA glycosylase.

@article{Faucher2009StructuralBF,
  title={Structural basis for the lack of opposite base specificity of Clostridium acetobutylicum 8-oxoguanine DNA glycosylase.},
  author={Fr{\'e}d{\'e}rick Faucher and Susan S. Wallace and Sylvie Doubli{\'e}},
  journal={DNA repair},
  year={2009},
  volume={8 11},
  pages={1283-9}
}
7,8-Dihydro-8-oxoguanine (8-oxoG) is the major oxidative product of guanine and the most prevalent base lesion observed in DNA molecules. Because 8-oxoG has the capability to form a Hoogsteen pair with adenine (8-oxoG:A) in addition to a normal Watson-Crick pair with cytosine (8-oxoG:C), this lesion can lead to a G:C-->T:A transversion after replication… CONTINUE READING