Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics.

@article{Downing2000StructuralBF,
  title={Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics.},
  author={Kenneth H Downing},
  journal={Annual review of cell and developmental biology},
  year={2000},
  volume={16},
  pages={89-111}
}
The microtubule cytoskeleton is a highly regulated system. At different times in the cell cycle and positions within the organism, microtubules can be very stable or highly dynamic. Stability and dynamics are regulated by interaction with a large number of proteins that themselves may change at specific points in the cell cycle. Exogenous ligands can disrupt the normal processes by either increasing or decreasing microtubule stability and inhibiting their dynamic behavior. The recent… CONTINUE READING

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