Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

  title={Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria},
  author={F. Schluenzen and R. Zarivach and Joe Harms and A. Bashan and A. Tocilj and R. Albrecht and A. Yonath and Franc{\"E}ois Franceschi},
  • F. Schluenzen, R. Zarivach, +5 authors FrancËois Franceschi
  • Published 2001
  • Biology, Medicine
  • Nature
  • Ribosomes, the site of protein synthesis, are a major target for natural and synthetic antibiotics. Detailed knowledge of antibiotic binding sites is central to understanding the mechanisms of drug action. Conversely, drugs are excellent tools for studying the ribosome function. To elucidate the structural basis of ribosome–antibiotic interactions, we determined the high-resolution X-ray structures of the 50S ribosomal subunit of the eubacterium Deinococcus radiodurans, complexed with the… CONTINUE READING
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