Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

@article{Schluenzen2001StructuralBF,
  title={Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria},
  author={Frank Schluenzen and Raz Zarivach and J Harms and Anat Bashan and Ante Tocilj and Renate Albrecht and Ada E. Yonath and Franc{\"E}ois Franceschi},
  journal={Nature},
  year={2001},
  volume={413},
  pages={814-821}
}
Ribosomes, the site of protein synthesis, are a major target for natural and synthetic antibiotics. Detailed knowledge of antibiotic binding sites is central to understanding the mechanisms of drug action. Conversely, drugs are excellent tools for studying the ribosome function. To elucidate the structural basis of ribosome–antibiotic interactions, we determined the high-resolution X-ray structures of the 50S ribosomal subunit of the eubacterium Deinococcus radiodurans, complexed with the… 

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Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action

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The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning

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