Structural basis for the inhibitor recognition of human Lyn kinase domain.

@article{Miyano2009StructuralBF,
  title={Structural basis for the inhibitor recognition of human Lyn kinase domain.},
  author={Nao Miyano and Takayoshi Kinoshita and Ryoko Nakai and Yasuyuki Kirii and Koichi Yokota and Toshiji Tada},
  journal={Bioorganic & medicinal chemistry letters},
  year={2009},
  volume={19 23},
  pages={6557-60}
}
Human Lyn tyrosine kinase is expressed in hematopoietic tissues and plays crucial roles in the signal transduction of hematopoietic immune system. Its excess activity is involved in several tumors. The crystal structure has revealed that the potent inhibitor staurosporine binds to human Lyn kinase domain at the ATP-binding site. The remarkable structural… CONTINUE READING