Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase.

@article{McGowan2009StructuralBF,
  title={Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase.},
  author={Sheena McGowan and Corrine J. Porter and Jonathan Lowther and Colin M. Stack and Sarah J. Golding and Tina S. Skinner-Adams and Katharine Trenholme and F. Teuscher and Sheila M. Donnelly and J. Grembecka and Artur Mucha and Pawel Kafarski and Ross Degori and Ashley M. Buckle and Donald L. Gardiner and James C. Whisstock and John Pius Dalton},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 8},
  pages={
          2537-42
        }
}
Plasmodium falciparum parasites are responsible for the major global disease malaria, which results in >2 million deaths each year. With the rise of drug-resistant malarial parasites, novel drug targets and lead compounds are urgently required for the development of new therapeutic strategies. Here, we address this important problem by targeting the malarial neutral aminopeptidases that are involved in the terminal stages of hemoglobin digestion and essential for the provision of amino acids… CONTINUE READING
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