Structural basis for the function of Clostridium difficile toxin B.

@article{Reinert2005StructuralBF,
  title={Structural basis for the function of Clostridium difficile toxin B.},
  author={D. Reinert and T. Jank and K. Aktories and G. Schulz},
  journal={Journal of molecular biology},
  year={2005},
  volume={351 5},
  pages={
          973-81
        }
}
Toxin B is a member of the family of large clostridial cytotoxins which are of great medical importance. Its catalytic fragment was crystallized in the presence of UDP-glucose and Mn2+. The structure was determined at 2.2 A resolution, showing that toxin B belongs to the glycosyltransferase type A family. However, toxin B contains as many as 309 residues in addition to the common chainfold, which most likely contribute to the target specificity. A superposition with other glycosyltransferases… Expand
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