Structural basis for the drug extrusion mechanism by a MATE multidrug transporter

@article{Tanaka2013StructuralBF,
  title={Structural basis for the drug extrusion mechanism by a MATE multidrug transporter},
  author={Yoshiki Tanaka and Christopher John Hipolito and Andr{\'e}s Daniel Maturana and Koichi Ito and Teruo Kuroda and Takashi Higuchi and Takayuki Katoh and Hideaki Kato and Motoyuki Hattori and Kaoru Kumazaki and Tomoya Tsukazaki and Ryuichiro Ishitani and Hiroaki Suga and Osamu Nureki},
  journal={Nature},
  year={2013},
  volume={496},
  pages={247-251}
}
Multidrug and toxic compound extrusion (MATE) family transporters are conserved in the three primary domains of life (Archaea, Bacteria and Eukarya), and export xenobiotics using an electrochemical gradient of H+ or Na+ across the membrane. MATE transporters confer multidrug resistance to bacterial pathogens and cancer cells, thus causing critical reductions in the therapeutic efficacies of antibiotics and anti-cancer drugs, respectively. Therefore, the development of MATE inhibitors has long… CONTINUE READING