Structural basis for the design of PPAR-gamma ligands: a survey on quantitative structure- activity relationships.

Abstract

The present review after providing a short overview on PPARs and their pleiotropic action focuses on the QSAR studies reported mainly for PPAR-gamma agonists. The different 3D and 2D QSAR models are discussed, their impact in better understanding of the mechanism of action is analyzed and their contribution in the design of new molecules is outlined. 

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