Structural basis for the deoxyribonucleic acid affinity of bleomycins.

@article{Kross1982StructuralBF,
  title={Structural basis for the deoxyribonucleic acid affinity of bleomycins.},
  author={J Kross and William David Henner and William A. Haseltine and Luz Mar{\'i}a Olivares Rodr{\'i}guez and Martin D. Levin and Sidney M Hecht},
  journal={Biochemistry},
  year={1982},
  volume={21 15},
  pages={3711-21}
}
The role of the bithiazole moiety of bleomycin in the interaction of the antibiotic with DNA has been studied by the use of synthetic bithiazole derivatives. The DNA affinity of individual C-terminal (bithiazole) analogues of bleomycin was measured in terms of the ability of these species to block the binding of bleomycin to DNA, as judged by diminution of… CONTINUE READING