Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-­ISA247 (voclosporin)

Abstract

E-ISA247 (voclosporin) is a cyclosporin A analogue that is in late-stage clinical development for the treatment of autoimmune diseases and the prevention of organ graft rejection. The X-ray crystal structures of E-ISA247 and its stereoisomer Z-ISA247 bound to cyclophilin A have been determined and their binding affinities were measured to be 15 and 61 nM… (More)
DOI: 10.1107/S0907444910051905

Topics

4 Figures and Tables

Cite this paper

@inproceedings{Kuglstatter2011StructuralBF, title={Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-­ISA247 (voclosporin)}, author={Andreas Kuglstatter and Francis W. Mueller and Eric A. Kusznir and Bernard Gsell and Martine Stihle and Ralf Thoma and Joerg Benz and Launa J Aspeslet and Derrick G Freitag and Michael Patrick Hennig}, booktitle={Acta crystallographica. Section D, Biological crystallography}, year={2011} }