Structural basis for the counter-transport mechanism of a H+/Ca2+ exchanger.

@article{Nishizawa2013StructuralBF,
  title={Structural basis for the counter-transport mechanism of a H+/Ca2+ exchanger.},
  author={Tomohiro Nishizawa and Satomi Kita and Andr{\'e}s Daniel Maturana and Noritaka Furuya and Kunio Hirata and Go Kasuya and Satoshi Ogasawara and Naoshi Dohmae and Takahiro Iwamoto and Ryuichiro Ishitani and Osamu Nureki},
  journal={Science},
  year={2013},
  volume={341 6142},
  pages={168-72}
}
Ca(2+)/cation antiporters catalyze the exchange of Ca(2+) with various cations across biological membranes to regulate cytosolic calcium levels. The recently reported structure of a prokaryotic Na(+)/Ca(2+) exchanger (NCX_Mj) revealed its overall architecture in an outward-facing state. Here, we report the crystal structure of a H(+)/Ca(2+) exchanger from Archaeoglobus fulgidus (CAX_Af) in the two representatives of the inward-facing conformation at 2.3 Å resolution. The structures suggested Ca… CONTINUE READING
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E. M. Schwarz, S. Benzer
Natl. Acad. Sci. U.S.A. 94, • 1024

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