Structural basis for the counter-transport mechanism of a H+/Ca2+ exchanger.

  title={Structural basis for the counter-transport mechanism of a H+/Ca2+ exchanger.},
  author={Tomohiro Nishizawa and Satomi Kita and Andr{\'e}s Daniel Maturana and Noritaka Furuya and Kunio Hirata and Go Kasuya and Satoshi Ogasawara and Naoshi Dohmae and Takahiro Iwamoto and Ryuichiro Ishitani and Osamu Nureki},
  volume={341 6142},
Ca(2+)/cation antiporters catalyze the exchange of Ca(2+) with various cations across biological membranes to regulate cytosolic calcium levels. The recently reported structure of a prokaryotic Na(+)/Ca(2+) exchanger (NCX_Mj) revealed its overall architecture in an outward-facing state. Here, we report the crystal structure of a H(+)/Ca(2+) exchanger from Archaeoglobus fulgidus (CAX_Af) in the two representatives of the inward-facing conformation at 2.3 Å resolution. The structures suggested Ca… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 30 times. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper


Publications citing this paper.
Showing 1-10 of 10 extracted citations


Publications referenced by this paper.


E. M. Schwarz, S. Benzer
Natl. Acad. Sci. U.S.A. 94, • 1024

Similar Papers

Loading similar papers…