Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers

  title={Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers},
  author={Nithya Baburajendran and Ralf Jauch and Clara Yueh Zhen Tan and Kamesh Narasimhan and Prasanna R. Kolatkar},
  booktitle={Nucleic acids research},
Smad proteins form multimeric complexes consisting of the 'common partner' Smad4 and receptor regulated R-Smads on clustered DNA binding sites. Deciphering how pathway specific Smad complexes multimerize on DNA to regulate gene expression is critical for a better understanding of the cis-regulatory logic of TGF-β and BMP signaling. To this end, we solved the crystal structure of the dimeric Smad4 MH1 domain bound to a palindromic Smad binding element. Surprisingly, the Smad4 MH1 forms a… CONTINUE READING
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