Structural basis for the broad substrate range of the UDP-sugar pyrophosphorylase from Leishmania major.

@article{Dickmanns2011StructuralBF,
  title={Structural basis for the broad substrate range of the UDP-sugar pyrophosphorylase from Leishmania major.},
  author={Achim Dickmanns and Sebastian Damerow and Piotr Neumann and Eike-Christian Schulz and Anne-Christin Lamerz and Françoise H. Routier and Ralf Ficner},
  journal={Journal of molecular biology},
  year={2011},
  volume={405 2},
  pages={461-78}
}
Nucleotide sugars and the enzymes that are responsible for their synthesis are indispensable for the production of complex carbohydrates and, thus, for elaboration of a protective cellular coat for many organisms such as the protozoan parasite Leishmania. These activated sugars are synthesized de novo or derived from salvaged monosaccharides. In addition to UDP-glucose (UDP-Glc) pyrophosphorylase, which catalyzes the formation of UDP-Glc from substrates UTP and glucose-1-phosphate, Leishmania… CONTINUE READING

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