Structural basis for the assembly of a nuclear export complex

  title={Structural basis for the assembly of a nuclear export complex},
  author={Yoshiyuki Matsuura and Murray Stewart},
The nuclear import and export of macromolecular cargoes through nuclear pore complexes is mediated primarily by carriers such as importin-β. Importins carry cargoes into the nucleus, whereas exportins carry cargoes to the cytoplasm. Transport is orchestrated by nuclear RanGTP, which dissociates cargoes from importins, but conversely is required for cargo binding to exportins. Here we present the 2.0 Å crystal structure of the nuclear export complex formed by exportin Cse1p complexed with its… CONTINUE READING
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