Structural basis for the agonist action at free fatty acid receptor 1 (FFA1R or GPR40)

@article{Rodrigues2018StructuralBF,
  title={Structural basis for the agonist action at free fatty acid receptor 1 (FFA1R or GPR40)},
  author={D. A. Rodrigues and P. S. M. Pinheiro and Thayssa Tavares da Silva Cunha Ferreira and S. Thota and C. A. M. Fraga},
  journal={Chemical Biology \& Drug Design},
  year={2018},
  volume={91},
  pages={668 - 680}
}
G‐protein‐coupled receptor 40 (GPR40) was recently identified as an interesting target for treatment of type 2 diabetes. The high level of expression in pancreatic beta cells and the dependence of glucose on stimulating the secretion of insulin led to great excitement in this field. The identification of this target was followed by the development of a series of agonists with great potential for the treatment of diabetes. All known agonists have the presence of a pharmacophoric carboxylic acid… Expand
Orphan G protein-coupled receptors: The role in CNS disorders.
Patent highlights April-May 2018.
  • H. Mucke
  • Chemistry, Medicine
  • Pharmaceutical patent analyst
  • 2018

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Identification of Residues Important for Agonist Recognition and Activation in GPR40*
Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability.
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