Structural basis for the activation of cholera toxin by human ARF6-GTP.

  title={Structural basis for the activation of cholera toxin by human ARF6-GTP.},
  author={Claire J O'Neal and Michael G. Jobling and Randall K. Holmes and Wim G. J. Hol},
  volume={309 5737},
The Vibrio cholerae bacterium causes devastating diarrhea when it infects the human intestine. The key event is adenosine diphosphate (ADP)-ribosylation of the human signaling protein GSalpha, catalyzed by the cholera toxin A1 subunit (CTA1). This reaction is allosterically activated by human ADP-ribosylation factors (ARFs), a family of essential and ubiquitous G proteins. Crystal structures of a CTA1:ARF6-GTP (guanosine triphosphate) complex reveal that binding of the human activator elicits… CONTINUE READING


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