Structural basis for the Golgi association by the pleckstrin homology domain of the ceramide trafficking protein (CERT).

@article{Sugiki2012StructuralBF,
  title={Structural basis for the Golgi association by the pleckstrin homology domain of the ceramide trafficking protein (CERT).},
  author={Toshihiko Sugiki and Koh Takeuchi and Toshiyuki Yamaji and Toshiaki Takano and Yuji Tokunaga and Keigo Kumagai and Kentaro Hanada and Hideo Takahashi and Ichio Shimada},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 40},
  pages={33706-18}
}
Ceramide transport from the endoplasmic reticulum to the Golgi apparatus is crucial in sphingolipid biosynthesis, and the process relies on the ceramide trafficking protein (CERT), which contains pleckstrin homology (PH) and StAR-related lipid transfer domains. The CERT PH domain specifically recognizes phosphatidylinositol 4-monophosphate (PtdIns(4)P), a characteristic phosphoinositide in the Golgi membrane, and is indispensable for the endoplasmic reticulum-to-Golgi transport of ceramide by… CONTINUE READING
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