Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein.

@article{Ferreon2009StructuralBF,
  title={Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein.},
  author={Josephine C Ferreon and Maria A. Martinez-Yamout and H Jane Dyson and Peter E. Wright},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 32},
  pages={13260-5}
}
The adenovirus early region 1A (E1A) oncoprotein mediates cell transformation by deregulating host cellular processes and activating viral gene expression by recruitment of cellular proteins that include cyclic-AMP response element binding (CREB) binding protein (CBP)/p300 and the retinoblastoma protein (pRb). While E1A is capable of independent interaction with CBP/p300 or pRb, simultaneous binding of both proteins is required for maximal biological activity. To obtain insights into the… CONTINUE READING