Structural basis for stop codon recognition in eukaryotes

@article{Brown2015StructuralBF,
  title={Structural basis for stop codon recognition in eukaryotes},
  author={Alan Brown and Sichen Shao and Jason Murray and Ramanujan S Hegde and V Ramakrishnan},
  journal={Nature},
  year={2015},
  volume={524},
  pages={493-496}
}
Termination of protein synthesis occurs when a translating ribosome encounters one of three universally conserved stop codons: UAA, UAG or UGA. Release factors recognize stop codons in the ribosomal A-site to mediate release of the nascent chain and recycling of the ribosome. Bacteria decode stop codons using two separate release factors with differing specificities for the second and third bases. By contrast, eukaryotes rely on an evolutionarily unrelated omnipotent release factor (eRF1) to… CONTINUE READING
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Ahighly conservedeukaryotic protein familypossessingproperties of polypeptide chain release factor

  • L. Frolova
  • Nature
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