Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

@article{Xu2000StructuralBF,
  title={Structural basis for signal transduction by the Toll/interleukin-1 receptor domains},
  author={Yingwu Xu and Xiao Tao and Baohe Shen and Tiffany Horng and Ruslan Medzhitov and James L Manley and Liang Tong},
  journal={Nature},
  year={2000},
  volume={408},
  pages={111-115}
}
Toll-like receptors (TLRs) and the interleukin-1 receptor superfamily (IL-1Rs) are integral to both innate and adaptive immunity for host defence. These receptors share a conserved cytoplasmic domain, known as the TIR domain. A single-point mutation in the TIR domain of murine TLR4 (Pro712His, the Lpsd mutation) abolishes the host immune response to lipopolysaccharide (LPS), and mutation of the equivalent residue in TLR2, Pro681His, disrupts signal transduction in response to stimulation by… Expand
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  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005
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