Structural basis for sequence-specific DNA recognition by an Arabidopsis WRKY transcription factor.

@article{Yamasaki2012StructuralBF,
  title={Structural basis for sequence-specific DNA recognition by an Arabidopsis WRKY transcription factor.},
  author={Kazuhiko Yamasaki and Takanori Kigawa and Satoru Watanabe and Makoto Inoue and Tomoko Yamasaki and Motoaki Seki and Kazuo Shinozaki and Shigeyuki Yokoyama},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 10},
  pages={7683-91}
}
The WRKY family transcription factors regulate plant-specific reactions that are mostly related to biotic and abiotic stresses. They share the WRKY domain, which recognizes a DNA element (TTGAC(C/T)) termed the W-box, in target genes. Here, we determined the solution structure of the C-terminal WRKY domain of Arabidopsis WRKY4 in complex with the W-box DNA by NMR. A four-stranded β-sheet enters the major groove of DNA in an atypical mode termed the β-wedge, where the sheet is nearly… CONTINUE READING

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