Structural basis for selectivity and toxicity of ribosomal antibiotics.

@article{Bttger2001StructuralBF,
  title={Structural basis for selectivity and toxicity of ribosomal antibiotics.},
  author={Erik C B{\"o}ttger and Burkhard Springer and Therdsak Prammananan and Y G Kidan and Peter Sander},
  journal={EMBO reports},
  year={2001},
  volume={2 4},
  pages={
          318-23
        }
}
Ribosomal antibiotics must discriminate between bacterial and eukaryotic ribosomes to various extents. Despite major differences in bacterial and eukaryotic ribosome structure, a single nucleotide or amino acid determines the selectivity of drugs affecting protein synthesis. Analysis of resistance mutations in bacteria allows the prediction of whether cytoplasmic or mitochondrial ribosomes in eukaryotic cells will be sensitive to the drug. This has important implications for drug specificity… CONTINUE READING

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 56 CITATIONS, ESTIMATED 49% COVERAGE

New Antibiotic Targets

VIEW 17 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

The impact of aminoglycosides on the dynamics of translation elongation.

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Elements of ribosomal drug resistance and specificity.

VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Development of a novel genetic system to create markerless deletion mutants of Bdellovibrio bacteriovorus.

VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Aminoglycoside interactions and impacts on the eukaryotic ribosome

VIEW 1 EXCERPT
CITES BACKGROUND

Antibiofilm activity of lichen secondary metabolites

VIEW 1 EXCERPT
CITES BACKGROUND

FILTER CITATIONS BY YEAR

2001
2020

CITATION STATISTICS

  • 5 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 35 REFERENCES

The Moleular Basis of Antibiotic Action

  • E. F. Gale, E. Cundliffe, P. E. Reynolds, M. H. Richmond, J. M. Waring
  • 1981
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Ribosomal RNA and translation.

VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL