Structural basis for retroviral integration into nucleosomes

  title={Structural basis for retroviral integration into nucleosomes},
  author={Daniel P. Maskell and Ludovic Renault and Erik Serrao and Paul Lesbats and Rishi Matadeen and Stephen Hare and Dirk Lindemann and Alan N. Engelman and Alessandro Ferreira Costa and Peter Cherepanov},
Retroviral integration is catalysed by a tetramer of integrase (IN) assembled on viral DNA ends in a stable complex, known as the intasome. How the intasome interfaces with chromosomal DNA, which exists in the form of nucleosomal arrays, is currently unknown. Here we show that the prototype foamy virus (PFV) intasome is proficient at stable capture of nucleosomes as targets for integration. Single-particle cryo-electron microscopy reveals a multivalent intasome–nucleosome interface involving… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 37 times over the past 90 days. VIEW TWEETS
28 Citations
48 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 28 extracted citations


Publications referenced by this paper.
Showing 1-10 of 48 references

A genome-wide map of adeno-associated virus-mediated human gene targeting

  • DR Deyle
  • Nat Struct Mol Biol
  • 2014

Similar Papers

Loading similar papers…