Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A

@article{Benoit2014StructuralBF,
  title={Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A},
  author={Roger Marc Benoit and Daniel Frey and Manuel Hilbert and Josta T. Kevenaar and Mara M. Wieser and Christian U. Stirnimann and David McMillan and Tom Ceska and Florence Lebon and Rolf Jaussi and Michel O. Steinmetz and Gebhard F. X. Schertler and Casper C. Hoogenraad and Guido Capitani and Richard A. Kammerer},
  journal={Nature},
  year={2014},
  volume={505},
  pages={108-111}
}
Botulinum neurotoxin A (BoNT/A) belongs to the most dangerous class of bioweapons. Despite this, BoNT/A is used to treat a wide range of common medical conditions such as migraines and a variety of ocular motility and movement disorders. BoNT/A is probably best known for its use as an antiwrinkle agent in cosmetic applications (including Botox and Dysport). BoNT/A application causes long-lasting flaccid paralysis of muscles through inhibiting the release of the neurotransmitter acetylcholine by… CONTINUE READING