Structural basis for recognition of acidic-cluster dileucine sequence by GGA1

@article{Shiba2002StructuralBF,
  title={Structural basis for recognition of acidic-cluster dileucine sequence by GGA1},
  author={Tomoo Shiba and Hiroyuki Takatsu and Terukazu Nogi and Naohiro Matsugaki and Masato Kawasaki and Noriyuki Igarashi and Mamoru Suzuki and Ryuichi Kato and Thomas Earnest and Kazuhisa Nakayama and Soichi Wakatsuki},
  journal={Nature},
  year={2002},
  volume={415},
  pages={937-941}
}
GGAs (Golgi-localizing, γ-adaptin ear homology domain, ARF-interacting proteins) are critical for the transport of soluble proteins from the trans-Golgi network (TGN) to endosomes/lysosomes by means of interactions with TGN-sorting receptors, ADP-ribosylation factor (ARF), and clathrin. The amino-terminal VHS domains of GGAs form complexes with the… CONTINUE READING