Structural basis for recognition of H3T3ph and Smac/DIABLO N-terminal peptides by human Survivin.

@article{Du2012StructuralBF,
  title={Structural basis for recognition of H3T3ph and Smac/DIABLO N-terminal peptides by human Survivin.},
  author={Jiamu Du and Alexander E Kelly and Hironori Funabiki and Dinshaw J. Patel},
  journal={Structure},
  year={2012},
  volume={20 1},
  pages={185-95}
}
Survivin is an inhibitor of apoptosis family protein implicated in apoptosis and mitosis. In apoptosis, it has been shown to recognize the Smac/DIABLO protein. It is also a component of the chromosomal passenger complex, a key player during mitosis. Recently, Survivin was identified in vitro and in vivo as the direct binding partner for phosphorylated Thr3… CONTINUE READING