Structural basis for recognition of 2',5'-linked oligoadenylates by human ribonuclease L.

@article{Tanaka2004StructuralBF,
  title={Structural basis for recognition of 2',5'-linked oligoadenylates by human ribonuclease L.},
  author={Nobutada Tanaka and Masayuki Nakanishi and Yoshio Kusakabe and Yoshikuni Goto and Yukio Kitade and Kazuo T. Nakamura},
  journal={The EMBO journal},
  year={2004},
  volume={23 20},
  pages={3929-38}
}
An interferon-induced endoribonuclease, ribonuclease L (RNase L), is implicated in both the molecular mechanism of action of interferon and the fundamental control of RNA stability in mammalian cells. RNase L is catalytically active only after binding to an unusual activator molecule containing a 5'-phosphorylated 2',5'-linked oligoadenylate (2-5A), in the N-terminal half. Here, we report the crystal structure of the N-terminal ankyrin repeat domain (ANK) of human RNase L complexed with the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Can’t RIDD off viruses

Front. Microbiol. • 2014
View 1 Excerpt

RNase-L control of cellular mRNAs: roles in biologic functions and mechanisms of substrate targeting.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research • 2014

References

Publications referenced by this paper.
Showing 1-10 of 55 references

A bipartite model of 2-5A-dependent RNase L.

The Journal of biological chemistry • 1997
View 9 Excerpts
Highly Influenced

Expression cloning

A Zhou, BA Hassel, RH Silverman
1993
View 5 Excerpts
Highly Influenced

Designed to be stable: crystal structure of a consensus ankyrin repeat protein.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 2 Excerpts
Highly Influenced

Data processing

SG Sedwick, SJ Smerdon
Acta Crystallogr D • 1999
View 4 Excerpts
Highly Influenced

Crystallography & NMR system: A new software suite for macromolecular structure determination.

Acta crystallographica. Section D, Biological crystallography • 1998
View 1 Excerpt
Highly Influenced

Refinement of macromolecular structures by the maximum-likelihood method.

Acta crystallographica. Section D, Biological crystallography • 1997
View 1 Excerpt
Highly Influenced

Automated refinement of protein models.

Acta crystallographica. Section D, Biological crystallography • 1993
View 2 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…