Structural basis for promiscuous PAM recognition in type I–E Cascade from E. coli

@article{Hayes2016StructuralBF,
  title={Structural basis for promiscuous PAM recognition in type I–E Cascade from E. coli},
  author={Robert P. Hayes and Yibei Xiao and Fran Ding and Paul B. G. van Erp and Kanagalaghatta R. Rajashankar and Scott Bailey and Blake Wiedenheft and Ailong Ke},
  journal={Nature},
  year={2016},
  volume={530},
  pages={499-503}
}
Clustered regularly interspaced short palindromic repeats (CRISPRs) and the cas (CRISPR-associated) operon form an RNA-based adaptive immune system against foreign genetic elements in prokaryotes. Type I accounts for 95% of CRISPR systems, and has been used to control gene expression and cell fate. During CRISPR RNA (crRNA)-guided interference, Cascade (CRISPR-associated complex for antiviral defence) facilitates the crRNA-guided invasion of double-stranded DNA for complementary base-pairing… CONTINUE READING
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