Structural basis for phototoxicity of the genetically encoded photosensitizer KillerRed.

  title={Structural basis for phototoxicity of the genetically encoded photosensitizer KillerRed.},
  author={Sergei Pletnev and Nadya G. Gurskaya and Nadya V. Pletneva and Konstantin A. Lukyanov and Dmitri M Chudakov and Vladimir I Martynov and Vladimir O. Popov and Mikhail V Kovalchuk and Alexander Wlodawer and Zbigniew Dauter and Vladimir Z. Pletnev},
  journal={The Journal of biological chemistry},
  volume={284 46},
KillerRed is the only known fluorescent protein that demonstrates notable phototoxicity, exceeding that of the other green and red fluorescent proteins by at least 1,000-fold. KillerRed could serve as an instrument to inactivate target proteins or to kill cell populations in photodynamic therapy. However, the nature of KillerRed phototoxicity has remained unclear, impeding the development of more phototoxic variants. Here we present the results of a high resolution crystallographic study of… CONTINUE READING
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