Structural basis for phosphorylation-dependent signaling in the DNA-damage response.

@article{Williams2005StructuralBF,
  title={Structural basis for phosphorylation-dependent signaling in the DNA-damage response.},
  author={Randall Williams and Nina Bernstein and Megan S. Lee and Melissa L. Rakovszky and Diana T Cui and Ruth Green and Michael Weinfeld and J N Mark Glover},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  year={2005},
  volume={83 6},
  pages={721-7}
}
The response of eukaryotic cells to DNA damage requires a multitude of protein-protein interactions that mediate the ordered repair of the damage and the arrest of the cell cycle until repair is complete. Two conserved protein modules, BRCT and forkhead-associated (FHA) domains, play key roles in the DNA-damage response as recognition elements for nuclear Ser/Thr phosphorylation induced by DNA-damage-responsive kinases. BRCT domains, first identified at the C-terminus of BRCA1, often occur as… CONTINUE READING