Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.

  title={Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.},
  author={Wenguang G. Liang and Catherine G Triandafillou and Teng-Yi Huang and Medel Manuel L Zulueta and Shiladitya Banerjee and Aaron R. Dinner and Shang-Cheng Hung and Wei-Jen Tang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={113 18},
CC chemokine ligand 5 (CCL5) and CCL3 are critical for immune surveillance and inflammation. Consequently, they are linked to the pathogenesis of many inflammatory conditions and are therapeutic targets. Oligomerization and glycosaminoglycan (GAG) binding of CCL5 and CCL3 are vital for the functions of these chemokines. Our structural and biophysical analyses of human CCL5 reveal that CCL5 oligomerization is a polymerization process in which CCL5 forms rod-shaped, double-helical oligomers. This… CONTINUE READING
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