Structural basis for nick recognition by a minimal pluripotent DNA ligase

@article{Nair2007StructuralBF,
  title={Structural basis for nick recognition by a minimal pluripotent DNA ligase},
  author={Pravin A. Nair and Jayakrishnan Nandakumar and Paul Smith and Mark Odell and Christopher D Lima and Stewart Shuman},
  journal={Nature Structural &Molecular Biology},
  year={2007},
  volume={14},
  pages={770-778}
}
Chlorella virus DNA ligase, the smallest eukaryotic ligase known, has pluripotent biological activity and an intrinsic nick-sensing function, despite having none of the accessory domains found in cellular ligases. A 2.3-Å crystal structure of the Chlorella virus ligase-AMP intermediate bound to duplex DNA containing a 3′-OH–5′-PO4 nick reveals a new mode of DNA envelopment, in which a short surface loop emanating from the OB domain forms a β-hairpin 'latch' that inserts into the DNA major… CONTINUE READING

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