Structural basis for molecular recognition of folic acid by folate receptors

@article{Chen2013StructuralBF,
  title={Structural basis for molecular recognition of folic acid by folate receptors},
  author={Chen Chen and Jiyuan Ke and Xudong Zhou and Wei Yi and Joseph S. Brunzelle and Jun Li and Eu-leong Yong and H. Eric Xu and Karsten Melcher},
  journal={Nature},
  year={2013},
  volume={500},
  pages={486-489}
}
Folate receptors (FRα, FRβ and FRγ) are cysteine-rich cell-surface glycoproteins that bind folate with high affinity to mediate cellular uptake of folate. Although expressed at very low levels in most tissues, folate receptors, especially FRα, are expressed at high levels in numerous cancers to meet the folate demand of rapidly dividing cells under low folate conditions. The folate dependency of many tumours has been therapeutically and diagnostically exploited by administration of anti-FR… CONTINUE READING