Structural basis for membrane targeting by the MVB12-associated β-prism domain of the human ESCRT-I MVB12 subunit.

@article{Boura2012StructuralBF,
  title={Structural basis for membrane targeting by the MVB12-associated β-prism domain of the human ESCRT-I MVB12 subunit.},
  author={Evzen Boura and James H Hurley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 6},
  pages={
          1901-6
        }
}
MVB12-associated β-prism (MABP) domains are predicted to occur in a diverse set of membrane-associated bacterial and eukaryotic proteins, but their existence, structure, and biochemical properties have not been characterized experimentally. Here, we find that the MABP domains of the MVB12A and B subunits of ESCRT-I are functional modules that bind in vitro to liposomes containing acidic lipids depending on negative charge density. The MABP domain is capable of autonomously localizing to… CONTINUE READING

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